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Post by SNNAP Board Admin on Nov 30, 2004 17:21:13 GMT -5
I just found SNNAP, and it looks great. I'm a brain researcher with interests in ion channels, synaptic transmission, addiction, and very lately neural networks. This forum may be very useful. Would anyone care to discuss what they're doing with SNNAP and how they are doing it? Maybe we can get some cool interaction going.
Dieter (DK Bartschat)
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Post by SNNAP Board Admin on Nov 30, 2004 17:36:08 GMT -5
Thank you for you interest in SNNAP. We have several projects ongoing. Generally, we use SNNAP to model well characterized small circuits or individual cells. For example, we are developing a multi-compartment model (127 compartments) of the Touch sensory cell in the leech and we are developing a 15 cell model of the neural circuit that mediates feeding behavior of Aplysia.
You may wish to examine the published reports that used SNNAP in their studies. These include:
Cai, Y, Baxter, D.A. and Crow, T. Computational study of enhanced excitability in Hermissenda: Membrane conductances modulated by 5-HT. J. Comput. Neurosci., 15: 105-121, 2003.
Flynn, M., Cai, Y., Baxter, D.A. and Crow, T. A computational study of the role of spike broadening in synaptic facilitation of Hermissenda. J. Comput. Neurosci., 15: 29-41, 2003.
Susswein AJ, Hurwitz I, Thorne R, et al. Mechanisms underlying fictive feeding in Aplysia: Coupling between a large neuron with plateau potentials activity and a spiking neuron J NEUROPHYSIOL 87 (5): 2307-2323 MAY 2002
Komendantov AO, Kononenko NI Caffeine-induced oscillations of the membrane potential in Aplysia neurons NEUROPHYSIOLOGY+ 32 (2): 77-84 MAR-APR 2000
Baxter DA, Canavier CC, Clark JW, et al. Computational model of the serotonergic modulation of sensory neurons in Aplysia J NEUROPHYSIOL 82 (6): 2914-2935 DEC 1999
Pelz C, Jander J, Rosenboom H, et al. I-A in Kenyon cells of the mushroom body of honeybees resembles shaker currents: Kinetics, modulation by K+, and simulation J NEUROPHYSIOL 81 (4): 1749-1759 APR 1999
KABOTYANSKI EA, ZIV I, BAXTER DA, et al. EXPERIMENTAL AND COMPUTATIONAL ANALYSES OF A CENTRAL PATTERN GENERATOR UNDERLYING ASPECTS OF FEEDING-BEHAVIOR OF APLYSIA NETH J ZOOL 44 (3-4): 357-373 1994
Ziv, I, Baxter, D.A. and Byrne, J.H. Simulator for neural networks and action potentials: description and application. J. Neurophysiol. 71: 294-308, 1994.
White, J.A., Ziv, I., Cleary, L.J., Baxter, D.A. and Byrne, J.H. The role of interneurons in controlling the tail-withdrawal reflex in Aplysia: a network model. J. Neurophysiol. 70: 1777-1786, 1993.
Doug Baxter
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